Four non-steroidal anti-inflammatory drugs(NSAIDs),naproxen, ibuprofen, ketoprofen and fenoprofen were enantiomerically determined on a commercially available Whelk-O1 chiral stationary phase by high performance liquid chromatography.
用WHELK O1手性色谱柱 ,在正相条件下测定了几种非甾体类解热镇痛药物萘普生、布洛芬、酮基布洛芬和苯氧布洛芬等中对映体的含量。
Fenoprofen calcium was generated from fenoprofen by salification with an overall yield of about 38.
以间羟基苯乙酮、溴苯为起始原料,经过醚化、Darzens缩合、水解、氧化等反应制得苯氧布洛芬,最后转化为钙盐,总收率38。
