Using resorcinol and phenyl acetic acid as raw material, ipriflavone was synthesized through two steps, the first was the synthesis of 7-hydroxyisoflavone, which was obtained with "one-pot", and the second was the synthesis of object product from the etherification reaction of 7-hydroxyisoflavone and 2-bromopropane.
以间苯二酚和苯乙酸为基本原料,"一锅煮"合成中间体7-羟基异黄酮,然后再与2-溴丙烷醚化生成目标产物,目标产物结构经光谱确证为伊普黄酮,总收率达90%,纯度达98%以上。
Objective :The aim of this study is to explore the role of aldosterone in the genesis of atherosclerosis and the protective effects of both aldosterone antagonist eplerenone and Tong-Xin-Luo(TXL), a traditional Chinese medicine.
方法:40只雄性SD大鼠给予高脂饮食、左颈总动脉内膜损伤、维生素D3注射,随机分成五组给予醛固酮、伊普利酮、通心络药物干预。
