OBJECTIVE: To investigate the changes of kinase activity or expression of the catalytic subunit of DNA-dependent protein kinase (DNA-PK)in a particle exposure-induced malignant transformed cell line of human bronchial epithelial cells as well as human lung cancer tissues.
结果:a粒子辐射诱发的人支气管上皮细胞癌变株BERP35T-1的DNA-PKcs表达水平比亲本细胞BEP2D提高30%,激酶活性显著提高。