A member of the homeobox NK_2family,human cardiac homeobox gene Csx is an essential transcription factor for early cardiac development.
人心脏同源(异型)框基因Csx是同源(异型)框基因家族NK2的成员之一 ,也是心脏早期发育必须的转录因子之一 。
Csx gene contains three conserved domains:the TN domain,homeodomain and the NK2_specific domain(NK2_SD).
Csx包含了 3个保守的结构域 :TN结构域、同源(异型)框结构域和NK2 SD结构域 。
Background & Aims : Caudal-related homeodomain transcription 2 - Cdx2, an intestinal specific transcription factor in intestinal mucosa villi and crypts, plays a key role in the development and maintenance of the intestinal epithelial phenotype.
背景及目的: 同源(异型)框转录因子—Cdx2(caudal-related homeodomain transcription 2)定位于肠上皮的绒毛和隐窝表面,是肠上皮特异性转录因子,Cdx2基因的表达可显著诱导未分化的细胞向肠上皮分化,对肠黏膜的分化与表型的维持起到关键作用。