4-Fenchylthiosemicarbazide (4) was synthesized from (-)-fenchone by a three-step reaction in a yield of 45%.
以(-)-葑酮为原料经中间体葑胺合成4-葑基氨基硫脲(4),4与醛缩合得到11个未见文献报道的葑基缩氨基硫脲(5),5用六氰合铁(III)酸钾氧化成环得到相应的2,5-二取代-1,3,4-噻二唑类化合物(6);产物的结构经IR,NMR和元素分析确认,并用X射线衍射法测定化合物6d的晶体结构。
